burden effect size in SMMAT

hanchenphd / GMMAT

Generalized linear Mixed Model Association Tests

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burden effect size in SMMAT #35

Closed agilly closed 3 years ago

agilly commented 3 years ago

SMMAT returns B.score and B.var. Since a burden collapses individual genotypes into a single virtual genotype, it should be possible to obtain a beta and se. Is there a way to calculate these from the score and variance?

hanchenphd commented 3 years ago

Yes! The effect size beta can be calculated as B.score/B.var, and the SE of beta can be calculated as 1/sqrt(B.var).

Best, Han

agilly commented 3 years ago

Thanks Han!