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hdng / clonevol

Inferring and visualizing clonal evolution in multi-sample cancer sequencing
GNU General Public License v3.0
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Question about node label #24

Closed d88020 closed 5 years ago

d88020 commented 5 years ago

Thank you for sharing such an amazing tool. I'm studying on relation between cirrhosis (N) and cholangiocarcinoma (T). I'm using clonevol for this reason. However, many nodes were both N and T at the same time. I want nodes that only N or T. Why are these nodes both N and T?

hdng commented 5 years ago

I don't know much about cirrhosis/cholangiocarcinoma, but technically, each node represents a clone. If a clone is founded (estimated fraction of its cells > 0) in multiple samples, then it is labeled with those samples. In this case, your T and N samples share a clone. The sphere of cells plot would help better visualize the clonal admixture of individual samples, complementary to the tree.