Figure 4 - Githubissues

[ ] a. Correlation of RAS pathway signature gene expression with mesenchymal exposure values of primary tumors.
[ ] b. Correlation of JUN/FOS target gene expression mesenchymal exposure values of primary tumors.
[x] c. RAS signature genes mapped to single cells
[x] d. JUN/FOS targets mapped to single cells
[ ] e. Enrichment of RAS pathway signature genes in relapse samples compared to matched primary samples.
[ ] f. Enrichment of target genes of JUN/FOS in relapse samples compared to matched primary samples.
[ ] g. Radar plots displaying exposure of three primary and relapsed tumor pairings
[ ] h. Enrichment analysis of the target genes regulated by the neuroblastoma specific master regulatory transcription factors in primary versus matched relapse samples.
[x] i. RASSF3 loci
[ ] j. ??? loci
[x] k. Overexpression of HRASv12in SK-N -BE2c neuroblastoma cells
[x] l. FACS analysis of TNFRSF12A/CD266 in cells with HRASv12 induction
[ ] m. TNFRSF12A expression over cell lines
[ ] n. TNFRSF12A expression MES and ADRN cell lines

hdsu-bioquant / project_NB_SE