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hms-dbmi / dseqr

single-cell and bulk RNA-seq analyses from counts → pathways → drug candidates.
https://docs.dseqr.com
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get single cell gex signature for connectivity mapping #75

Closed alexvpickering closed 5 years ago

alexvpickering commented 5 years ago

Relevant paper on cross-sample comparisons:

https://www.biorxiv.org/content/biorxiv/early/2019/07/26/713412.full.pdf

TLDR: pseudo-bulk counts give the best results