hms-dbmi / hidive-dmp-requirements

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Expression matrices must be annotated with the type of normalization that has been applied #24

Open keller-mark opened 11 months ago

keller-mark commented 11 months ago

See https://github.com/chanzuckerberg/single-cell-curation/blob/main/schema/4.0.0/schema.md#x-matrix-layers for reasonable requirements about which types of normalization to require for gene expression matrices. We should require at the very least the raw counts, which we can always normalize further ourselves. Any additional normalized matrix should be stored with an informative name about what type of normalization/transformation was applied.