hputnam / Meth_Compare

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standardize estimated fraction of genome-wide CpGs to genome size (SUPP FIG 3) #100

Closed shellywanamaker closed 3 years ago

shellywanamaker commented 4 years ago

Address Alan and John's comments about standardizing supp fig 3 by genome size

Alan: Not sure if this makes sense, but have you thought about presenting some of these results using a depth standardized by genome size? It seems some of these differences here might be driven in part by the big difference in genome size, so if you standardize by genome size you might find similar estimates for % CpG per unit depth for each method among species. This could also help generalize this result and might be more informative for those looking to this paper to make decisions about other inverts (with different genome sizes).

John: Echoing Alan's comment earlier, it may be worthwhile to standardize these comparisons by genome size.