hubmapconsortium / sc-atac-seq-pipeline

ATAC-seq pipelines for HuBMAP
MIT License
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Matrix decomposition failure in smoothing cell-by-gene matrix #42

Open mruffalo opened 2 years ago

mruffalo commented 2 years ago

From @jswelling:

Smoothing cell-by-gene matrix
Epoch: checking the inputs ...
Error in A %*% data.use :
  Cholmod error 'problem too large' at file ../Core/cholmod_sparse.c, line 89
Calls: runMagic -> %*% -> %*%

This can likely be addressed by splitting the matrix by subsets of cells, smoothing each piece, then concatenating -- unlike https://github.com/hubmapconsortium/sc-atac-seq-pipeline/issues/41.