humanlongevity / HLA

xHLA: Fast and accurate HLA typing from short read sequence data
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full resolution result strange #53

Open xhy1219 opened 4 years ago

xhy1219 commented 4 years ago

Hi I just installed xHLA manually(can not use docker) and test it using test.bam. The result was identical with the one put on the home page. (It was also good with full option)

But when I test my own sample, it gave multiple full resolution type for some alleles. Is it normal? I do not know which one should trust. Or there are some problems? (I did the preprocessing using get-reads-alt-unmap.sh, for the hg38.chr6.fna reference, I downloaded it from http://hgdownload.cse.ucsc.edu/goldenPath/hg38/chromosomes/chr6.fa.gz )

type full total good rank A01:01 A01:01:01:01;A01:01:03;A01:01:08;A01:01:14;A01:01:20;A01:01:23;A01:01:34;A01:01:46;A01:01:48;A01:01:52;A01:01:58;A01:01:65;A01:01:66;A01:01:71;A01:01:73 5 5 1 B46:10 B46:10 2 2 1 C16:85 C16:85 4 4 1 DPB117:01 DPB117:01 2 2 1 DQB102:01 DQB102:01:01;DQB102:01:08 2 2 1 DQB103:01 DQB103:01:01:01 3 3 1 DRB107:01 DRB107:01:01:01 3 3 1 DRB111:01 DRB111:01:01;DRB111:01:07;DRB111:01:13;DRB111:01:15;DRB111:01:16;DRB111:01:20 2 2 1