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igrabski / sc-SHC

Significance analysis for clustering single-cell RNA-sequencing data
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ATACseq support #17

Closed gszeto0 closed 1 year ago

gszeto0 commented 1 year ago

First, thanks for a much-needed method for determining clustering significance. It's been super valuable for ongoing scRNAseq analysis.

Are you planning on extending and testing the method to other data types/dimensionality reductions? In particular, ATACseq would be quite valuable, but many methods use LSI for ATAC instead of PCA.

igrabski commented 1 year ago

Thanks so much for trying out our approach!

I think extending these ideas to other modalities and dimensionality reductions would be very interesting, but would require some relatively involved development (e.g. we would need a different underlying probabilistic model). I would be interested in these ideas in the future, but unfortunately we do not have current plans to do so now.