python3-appdirs is dead upstream[1] and its Debian maintainer has indicated
that it should not be included in trixie[2]. A recommended replacement is
python3-platformdirs[3], which is a fork of appdirs with a very similar API.
Please migrate from appdirs to platformdirs or some other replacement,
so that appdirs can be removed.
As reported in https://bugs.debian.org/1067987
The same applies to pycuda.