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ins-amu / BVEP

The Bayesian Virtual Epileptic Patient: a probabilistic framework designed to infer the spatial map of epileptogenicity in a personalized large-scale brain model of epilepsy spread
GNU General Public License v3.0
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PZ node is not active #3

Open nana-zhang opened 2 years ago

nana-zhang commented 2 years ago

Hello, I'm trying to use BVEP. I use the brain imaging data of our own epilepsy patients and generate the structural connection matrix by running tvb- recon. Then I try to use the structural connection matrix for forward simulation. I run two codes, BVEP/ TVB / forwardsimulation VEPmodel patient1. Ipynb and BVEP / TVB / forwarssimulation VEPmodel SEEG_ patient1. Ipynb, as in the code, set nodes 6 and 34 as EZ, 5, 11 and 27 as PZ, and the rest as Hz. However, I found that the result only shows that EZ node is active, and no PZ node is responding. What is the reason? Is it related to the patient's connection matrix? Is this a normal phenomenon? Screenshot from 2022-03-04 18-26-24 Screenshot from 2022-03-04 20-05-35

mhashemi0873 commented 2 years ago

The propagation needs strong coupling K and dramatically depends on the structural connectivity (SC) matrix, as well as excitability value. One solution is to increase coupling K, or increase the excitability value for these nodes closer to the critical value -2.05. A simpler way is to increase coupling between EZ and PZ, according to the clinical hypothesis.