instructlab / taxonomy

Taxonomy tree that will allow you to create models tuned with your data
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adding first snx27 biorxiv manuscript #1204

Closed aevo98765 closed 5 days ago

aevo98765 commented 6 days ago

If your PR is related to a contribution to the taxonomy, please, fill out the following questionnaire. If not, replace this whole text and the following questionnaire with whatever information is applicable to your PR.

Describe the contribution to the taxonomy

Input given at the prompt

   Does snx27 have a pdz domain and if so what does it do?

Response from the original model

Yes, SNX27 does contain a Pdz (Protein-Doz) domain. This domain is primarily 
involved in binding to specific phosphatidylinositol lipids present on the 
membrane of various organelles within the cell. By interacting with these 
lipids, the SNX27 protein can efficiently recognize and bind to its cargo 
molecules, facilitating their transport along the secretory pathway.

Response from the fine-tuned model

  SNX27 does contain a PDZ (PDZ) domain, which is a conserved region of approximately 100 
amino acids that binds to acidic lipids on the surface of endosomes. This interaction is 
crucial for the formation and fission of transport vesicles during endocytic sorting.
* The PDZ domain of SNX27 is responsible for binding to acidic lipids on the surface of 
early endosomes, which helps recruit other proteins involved in membrane remodeling and 
fission.
* This interaction also contributes to the specificity of cargo recognition during 
endocytic sorting by ensuring that only certain cargoes are included in transport 
vesicles.

Contribution checklist

instruct-lab-bot[bot] commented 6 days ago

Beep, boop 🤖, Hi, I'm @instructlab-bot and I'm going to help you with your pull request. Thanks for you contribution! 🎉

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[!NOTE] Currently only maintainers belongs to [[taxonomy-triagers taxonomy-approvers taxonomy-maintainers labrador-org-maintainers instruct-lab-bot-maintainers]] teams are allowed to run these commands.

jjasghar commented 5 days ago

Hello! Thank you for this submission. Unfortunately, we need you to fill out the knowledge submission form before we can accept any submission from you. Please take a moment to fill it out so we can get this through the proper channels.

I will close this for now, but if/when you get the submission approval, you can reopen the PR, and we can look at adding it to the knowledge submission process.

aevo98765 commented 5 days ago

Ahh, OK no problems I will get this filled out ASAP!