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【大咖面对面】南方科技大学靳文菲教授分享：发展单细胞组学技术研究肿瘤免疫 #3493

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【大咖面对面】南方科技大学靳文菲教授分享：发展单细胞组学技术研究肿瘤免疫 by 实验小白


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北京时间6月8日(周四)上午9:00，南方科技大学靳文菲教授分享：发展单细胞组学技术研究肿瘤免疫

  • Zoom Meeting ID: 16108032958;

  • Zoom link: https://nih.zoomgov.com/j/16108032958

  • 或扫描下方二维码免费参会：

     靳文菲教授长期从事群体遗传学和精准医学相关研究，通过开发基因组和表观基因组等高通量实验和计算方法，进行复杂性状的基因定位, 染色质远距离互作调控, 人群遗传结构和单细胞测序等研究。共发表论文和图书章节20多篇，总引用近700次（Google scholar）。靳文菲博士2006年毕业于郑州大学，2012年1月在中科院上海生科院金力院士和徐书华研究员指导下获得计算生物学博士，毕业后留所做助理研究员。2013年1月加入美国国立卫生研究院（NIH）赵可吉博士课题组从事博士后研究。2017年加入南方科技大学生物系。主要成果包括:【1】开发了单细胞DNase测序(Jin, et al. 2015 Nature), 该技术将为个性化医疗提供关键基因调控信息; 【2】长期系统的群体遗传学研究，对人群混合和遗传疾病基因研究有独特贡献（Jin et al, 2012 Genome Res; Jin et al, 2012 AJHG; Jin et al, 2012 HMG; Jin, et al. 2014 EJHG）。

往期会议视频：

  1. Di Wang（Zhejiang University）：An Ionic Control of Immunometabolism； 

    https://www.bilibili.com/video/BV1BB4y1U7he?

  2. Eran Elinav（Weizmann Institute of Science, Israel）：Host Microbiome Interactions in Health and Disease； 

    https://www.bilibili.com/video/BV1e541127kT?

  3. Peng Jiang（NCI/NIH）：Cytokines signaling activity at the tissue and single-cell level； 

    https://www.bilibili.com/video/BV1T94y1Z7Ne?

  4. Hao Wu（HMS/BCH）：Structural elucidation of inflammasome biology； 

    https://www.bilibili.com/video/BV1hT4y1U72k?

  5. Nan-Ping Weng（NIA/NIH）：Aging of T cell immunity measured by TCR repertoire and CD8+ T cell response； 

    https://www.bilibili.com/video/BV1QF411t7W2?

  6. Jenny Ting（UNC）：The all-encompassing importance of innate immune receptors； 

    https://www.bilibili.com/video/BV1H3411Y7Ry?

  7. Luke O'Neill（Trinity College Dublin）：Adventures in Inflammation Research； 

    https://www.bilibili.com/video/BV1iq4y127cL?

  8. Wanjun Chen（NIDCR）：The development and function of regulatory T cells； 

    https://www.bilibili.com/video/BV1PP4y1G7Xw?

  9. Burkhard Becher （Univ. of Zurich）：Immunopathology:the monocyte to phagocyte transition in tissue inflammation； 

    https://www.bilibili.com/video/BV1BL41177WC?

  10. Feng Shao（NIBS）：Pyroptosis in antibacterial and antitumor immunity ； 

    https://www.bilibili.com/video/BV1HS4y1d7xN?

  11. Michael Lenardo（NIAID）：Gene identification in congenital immune diseases lead to precision medicine therapies； 

    https://www.bilibili.com/video/BV1CU4y1u7NS?

  12. Ping-Chih Ho（Ludwig Institute for Cancer Research, Lausanne）：Mitochondrial dynamics orchestrate T cell anti-tumor immunity； 

    https://www.bilibili.com/video/BV1bL4y167oR?

  13. P'ng Loke（NIAID）：Heterogeneity of Type 2 Immune Responses during helminth infections； 

    https://www.bilibili.com/video/BV1D44y1b7qE?

  14. Ken Cadwell（NYU）：Host adaptations to microbial diversity； 

    https://www.bilibili.com/video/BV1rq4y1Z7fN?

  15. Chen Dong（Tsinghua）：Regulation of type 17 immunity in health and diseases； 

    https://www.bilibili.com/video/BV1sh411W7jj?

  16. Haitao Wen（Ohio State）：Antiviral function of O-GlcNAc transferase: immunity plus metabolism； 

    https://www.bilibili.com/video/BV1gq4y1u7b1?

  17. Zihai Li（Ohio State）：Merging Roles of Platelets in Immuno-Oncology: Old Dog But Not New Tricks； 

    https://www.bilibili.com/video/BV1iL4y1a7wB?

  18. Ben Afzali（NIDDK）：Next generation approaches to untangling COVID-19； 

    https://www.bilibili.com/video/BV1Xv411P7FM?

  19. Thaddeus Stappenbeck（Cleveland Clinic）：Paneth cells and their role in innate immunity and shaping the microbiome； 

    https://www.bilibili.com/video/BV14y4y1V7FG?

  20. Feilong Meng（SIBCB）：Repair of AID-initiated DNA lesions in B cells； 

    https://www.bilibili.com/video/BV1Eq4y1n7ji?

  21. Xuanming Yang（Shanghai Jiaotong Unvi.）：Engineering chimeric antigen receptor modified T cells against solid tumor； 

    https://www.bilibili.com/video/BV1ib4y1r7Wh?

  22. Lai Guan Ng（Singapore Immunology Network, A*STAR）：Neutrophils: The Power of Many； 

    https://www.bilibili.com/video/BV1ZM4y1P7Pf?

  23. Wenwen Zeng（Tsinghua University）：Peripheral neural control of lipid metabolism and neural-immune response； 

    https://www.bilibili.com/video/BV13L411n7LP?

  24. Yichuan Xiao（Institute of Nutrition&Health）：CAS KU-mediated DNA sensing in T cell potentiates aging-induced autoimmunity； 

    https://www.bilibili.com/video/BV1og411T79K?

  25. Pengcheng Bu（CAS-Biophysics）：Metabolism drives coloerctal cancer metastasis； 

    https://www.bilibili.com/video/BV18b4y1k7JW?

  26. Di Yu（U. Queensland）：Follicular helper T cells: from autoimmunity to vaccination； 

    https://www.bilibili.com/video/BV19h411h75Q?

  27. Linrong Lu（Zhejiang U.）：MINK1 kinase: a missing link between environmental stress and T cell immunity； 

    https://www.bilibili.com/video/BV1tU4y137qt?

  28. Lei Zhang（Shenzhen Bay Lab）：Dissecting the mechanisms of cancer immunotherapies by single-cell analyses； 

    https://www.bilibili.com/video/BV1ZU4y1g77F?

  29. Weiping Zou（U Mich）：Metabolic impact on cancer immunity and therapy； 

    https://www.bilibili.com/video/BV1GB4y1T7hU?

  30. Lanfen Chen（Xiamen U.）：Function of Hippo Signalling in Macrophage and Host Antimicrobial Defense； 

    https://www.bilibili.com/video/BV1SK4y1u7gW?

  31. Jagan Muppidi（NCI）：FAS-mediated counterselection in the germinal center and lymphoma； 

    https://www.bilibili.com/video/BV1Zv411n7aG?

  32. Xuyu Zhou（Institute of Microbiology, CAS）：Control of Treg heterogeneity and stability； 

    https://www.bilibili.com/video/BV16X4y1A7iT?

  33. Hai Qi（Tsinghua）：Affinity maturation in the germinal center: from T cells to B cells and back； 

    https://www.bilibili.com/video/BV1s5411M7qC?

  34. Meng Xu（Tsinghua）：Cell-type-specific m6A programs underlying immune evasion； 

    https://www.bilibili.com/video/BV1J5411M7YY?

  35. Guohong Hu（CAS-Nutrition & Health）：Microenvironmental regulation of breast cancer metastatic colonization； 

    https://www.bilibili.com/video/BV1GK4y1A7WR?

  36. Weiqiang Chen（NYU）：Microengineered Biosystems for Cancer Immunotherapy Screening: From biology to mechanics； 

    https://www.bilibili.com/video/BV1wV411E7xv?

  37. Tak Mak（University of Toronto）：Beyond Immune Checkpoint Blockade: Emerging Strategies； 

    https://m.bilibili.com/video/BV1tA4y1D7G8

  38. Rogelio Hernandez（Stanford University）：T cell circuits that senses antigen density with an ultrasensitive threshold； 

    https://www.bilibili.com/video/BV16u411z7TZ

  39. Soman Ninan Abraham（Duke University）：Mast cells in Immune Surveillance； 

    https://www.bilibili.com/video/BV1fB4y1Q7vc

  40. Jing Yang（Peking University）：Neuroimmune regulation of spleen immunity and beyond； 

    https://www.bilibili.com/video/BV1d341137Qq

  41. John Luken（University of Virginia）：Role of DNA Damage Surveillance by the Innate Immune System in Neurodevelopment； 

    https://www.bilibili.com/video/BV1WF411F7Hu

  42. Hanrui Zhang（Columbia University）：Macrophage Biology and Functional Genomics in Cardiometabolic Diseases； 

    https://www.bilibili.com/video/BV1pY411T7XA

  43. Penghui Zhou（Sun Yat-Sen University）：Defined Tumor Antigen Specific T Cells Potentiate Personalized TCR-T Cell Therapy； 

    https://www.bilibili.com/video/BV1Yr4y1g79z

  44. Hiroshi Ohno（RIKEN Center for Integrative Medical Sciences）：Gut microbial carbohydrate metabolism impacts host insulin resistance； 

    https://www.bilibili.com/video/BV1Bv4y1T7Nv

  45. Xiaolei Su（Yale University）：CAR as a tool for deciphering transmembrane signaling and reprogramming immune； 

    https://www.bilibili.com/video/BV1AB4y1p78a

  46. Bing Su（Shanghai Jiaotong University School of Medicine）：The immune receptor signaling and function mediated by the conserved MAP kinase kinase kinase MEKK2； 

    https://www.bilibili.com/video/BV1sY4y177LT

  47. Brian Glubransen（Michigan State University）：Enteric glia: neuroimmune modulators of the gastrointestinal tract； 

    https://www.bilibili.com/video/BV1rT411E72e

  48. Guoliang Cui（DKFZ, Germany）：How long does an exhausted T cell survive in tumor； 

    https://www.bilibili.com/video/BV14B4y1V7or

  49. Fubin Li（Shanghai Jiaotong University）：Immunoglobulin G subclass in health and diseases； 

    https://www.bilibili.com/video/BV1Ue4y1o7Y9

  50. Tony Wyss-Coray（Stanford University）：Young blood for old brains； 

    https://www.bilibili.com/video/BV1He411g7G1

  51. Jennifer Gommerman（University of Toronto）：Fantastic IgA Plasma Cells and where to find them； 

    https://www.bilibili.com/video/BV13V4y1u77t

  52. Jianqing Xu（Fudan University）：Novel Car T: from membrane target triggered killing to environment condition activated killing； 

    https://www.bilibili.com/video/BV1DP4y1d7ag

  53. Lisa Denzin（Rutgers University）：Non classical MHC class II molecules modulate the immune response to chronic viral infections； 

    https://www.bilibili.com/video/BV1ie4y1r7uu

  54. Zheng Zhang（South University of Science and Technology）：Immune pathogenesis and antibody responses in COVID-19； 

    https://www.bilibili.com/video/BV1Fd4y1i7Y8

  55. Rafi Ahmed（Emory University）：T Cell Lifestyle during Chronic Viral Infection and Cancer: Implications for Immunotherapy； 

    https://www.bilibili.com/video/BV1Hd4y117bF

  56. Shang Cai（Westlake University）：The lurking culprit of caner metastasis in the bac-ground； 

    https://www.bilibili.com/video/BV1xg411v7VP

  57. Grégoire Altan-Bonnet（NCI / NIH）：The immune system as a liquid brain?How machine learning helps in modeling self/non-self discrimination by T cells… and vice versa. 

    https://www.bilibili.com/video/BV13d4y1t7ZT

  58. Susan Kaech（Salk Institute）：Co-opting Immune cells to Support Cancer Progression through Metabolic Reprogram； 

    https://www.bilibili.com/video/BV1BK411R7iw

  59. Li-Guo Zhan（Peking University）：Challenge and opportunity in research of autoimmune disease； 

    https://www.bilibili.com/video/BV148411p7PP

  60. Kiyoshi Takeda（Osaka University）：The host-microbiota interaction for the maintenance of intestinal homeostasis； 

    https://www.bilibili.com/video/BV1vR4y167jz

  61. Rio Sugimura（University of Hong Kong）：The role of immune checkpoint in human embryonic organoids； 

    https://www.bilibili.com/video/BV1gD4y1V7wD

  62. Xiaoyun Dai（Yale University）：Engineering Next Generation CAR-T Cells with CRISPR； 

    https://www.bilibili.com/video/BV1hM411F7hc

  63. Andrew Wang（Yale University）：Schrödinger’s Mouse； 

    https://www.bilibili.com/video/BV1ts4y1x7Ks

  64. Marc Jenkins（University of Minnesota）：How antigen-specific helper T cells support cell-mediated and humoral immunity to infection； 

    https://www.bilibili.com/video/BV15A411B7R1

  65. Axel Kallies（University of Melbourne）：Development and maintenance of cytotoxic T cells in chronic infection； 

    https://www.bilibili.com/video/BV1LM4y1Z7cC

  66. Yi Zhong（Shanghai Immune Therapy Institute）：Natural genetic variation reveals principles of epigenetic regulation in T cell； 

    https://www.bilibili.com/video/BV1EP411f7GY

  67. Christopher Garcia（Stanford University）：Exploring and exploiting principles of antigen recognition through protein engineering； 

    https://www.bilibili.com/video/BV1fP411Z7t9

  68. Enfu Hui（UCSD）：Unconventional signaling mode of CD28 and CTLA4: when their ligands get onto T cells； 

    https://www.bilibili.com/video/BV1tL411S7CQ

  69. Masanori Aikawa（BWH/HMS）：Systems approach to target discovery for inflammatory vascular disease； 

    https://www.bilibili.com/video/BV1gT411W71U

  70. Wei Hu（Yale University）：Dynamic control of regulatory T cell function by autoimmune inflammation； 

    https://www.bilibili.com/video/BV1ts4y1Q7BJ

  71. Xing Chang（Westlake University）：Post-transcriptional regulation in lymphocytes； 

    https://www.bilibili.com/video/BV17h411F7Br

  72. Brian Kim（Icahn School of Medicine at Mount Sinai）：Sensing Inflammation in the Skin and Beyond； 

    https://www.bilibili.com/video/BV1fs4y1q7GC

  73. Keji Zhao（NHLBI/NIH）：Regulation of T cell differentiation by three-dimensional chromatin interactions； 

    https://www.bilibili.com/video/BV1Gh4y1d7KK

  74. Adam Barb（University of Georgia）：N-glycosylation of both the antibody and an antibody-binding receptor impacts cell activation； 

    https://www.bilibili.com/video/BV1oP411D7NH

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