Closed ixxmu closed 11 months ago
分享是一种态度
题目:Identification of a tumour immune barrier in the HCC microenvironment that determines the efficacy of immunotherapy
期刊:Journal of Hepatology (IF: 26)
发表时间:2023
单位:上海交大 Lianxin Liu
组织类型:肝细胞癌。接受抗PD-1治疗有反应的3个病人,没有反应的5个病人,3个正常
eight patients with HCC receiving anti-PD-1 treatment (non-responders, n = 5; responders, n = 3) and adjacent normal tissue sections (n = 3). 组学:ST, scRNA
测序平台:10X Genomics
样本数:ST (11个样本,8个病人+3个正常), scRNA (6个non-responders;normal)
细胞数:83,799个细胞
数据下载:Mendeley Data (skrx2fz79n)
TIB: tumor immune barrier. 肿瘤免疫屏障
T-cell-inflamed gene expression profile(T细胞表达基因特征)是一种基因表达谱,用于预测临床对 PD-1 抑制治疗的反应。它是根据与IFN-c相关的mRNA的基因表达特征来评估肿瘤组织中T细胞的浸润情况和免疫活性。T-cell-inflamed gene expression profile可以帮助研究人员了解T细胞在肿瘤免疫中的作用,以及判断肿瘤免疫治疗的疗效。
we calculated the signature score of the T-cell-inflamed gene expression profile (GEP),23 an IFN-c–related mRNA profile iomarker to predict clinical response to PD-1 blockade, in each spot and theaverage expression of GEP genes in each spatial cluster.
Tumor microarray (TMA,组织肿瘤芯片技术):对切片进行染色,以标记感兴趣的生物标记物.
附图
主图:
阻断SPP1或在小鼠中特异性删除巨噬细胞中的Spp1可以破坏TIB结构并增强肝细胞癌对免疫治疗的敏感性。
Blockade of SPP1 or macrophage-specific deletion of Spp1 in mice can destroy the TIB structure and sensitize HCC to immunotherapy.
如果你对单细胞转录组研究感兴趣,但又不知道如何入门,也许你可以关注一下下面的课程
看完记得顺手点个“在看”哦!
长按扫码可关注
分享是一种态度
题目:Identification of a tumour immune barrier in the HCC microenvironment that determines the efficacy of immunotherapy
期刊:Journal of Hepatology (IF: 26)
发表时间:2023
单位:上海交大 Lianxin Liu
组织类型:肝细胞癌。接受抗PD-1治疗有反应的3个病人,没有反应的5个病人,3个正常
eight patients with HCC receiving anti-PD-1 treatment (non-responders, n = 5; responders, n = 3) and adjacent normal tissue sections (n = 3). 组学:ST, scRNA
测序平台:10X Genomics
样本数:ST (11个样本,8个病人+3个正常), scRNA (6个non-responders;normal)
细胞数:83,799个细胞
数据下载:Mendeley Data (skrx2fz79n)
TIB: tumor immune barrier. 肿瘤免疫屏障
T-cell-inflamed gene expression profile(T细胞表达基因特征)是一种基因表达谱,用于预测临床对 PD-1 抑制治疗的反应。它是根据与IFN-c相关的mRNA的基因表达特征来评估肿瘤组织中T细胞的浸润情况和免疫活性。T-cell-inflamed gene expression profile可以帮助研究人员了解T细胞在肿瘤免疫中的作用,以及判断肿瘤免疫治疗的疗效。
we calculated the signature score of the T-cell-inflamed gene expression profile (GEP),23 an IFN-c–related mRNA profile iomarker to predict clinical response to PD-1 blockade, in each spot and theaverage expression of GEP genes in each spatial cluster.
Tumor microarray (TMA,组织肿瘤芯片技术):对切片进行染色,以标记感兴趣的生物标记物.
附图
主图:
阻断SPP1或在小鼠中特异性删除巨噬细胞中的Spp1可以破坏TIB结构并增强肝细胞癌对免疫治疗的敏感性。
Blockade of SPP1 or macrophage-specific deletion of Spp1 in mice can destroy the TIB structure and sensitize HCC to immunotherapy.
如果你对单细胞转录组研究感兴趣,但又不知道如何入门,也许你可以关注一下下面的课程
看完记得顺手点个“在看”哦!
长按扫码可关注
https://mp.weixin.qq.com/s/mIItweNYaDjW6tL8xT_hkA