Characterize lung-specific transcriptomic features

[j3gu]

Lung-specific gene expression

• Identify the expression pattern for the marker genes of tissue-resident T cells
  • [ ] integrate chromatin profiles with expression to validate the utility of those marker genes
• Identify the target genes for the enhancers with high causal probability
  • [ ] make a heat-map plot to visualize the expression/accessibility of these enhancers across immune populations
• Understand the function of the identified gene sets through GO analyses

[j3gu]

[j3gu]

Separate into panels seems easier to make comparison.

[j3gu]

T cell subsets:

[j3gu]

• Not much changes in expression across tissues
• BACH2 has much higher expression in naive B cells.
• T cell subsets show some cell type specific expression for TFs