Adds the CDR/FWR annotations to data summary file.
@WillHannon-MCB , this should have the additional annotations then for representation in interactive plots. I think the viz I imagine would be to be able to have four sets of selectors, as toggle-switches where ideally you'd be able to toggle on or off multiple values in each of the sets of selections -- one for selecting mutations based on the wt amino acid (column wildtype), one for selecting mutations based on th emutated amino acid (column mutant), one for selecting sites based on their heavy versus light chain (column chain), one for selecting sites based on their CDR/FWR annotation (column annotation). Tooltip on points would give the mutation string as represented in the column mutation, which gives the sites indexed in the desired "IMGT" nomenclature as well as an indicator for heavy/light chain.
While I'm listing these things just so it's here in one place, similarly on interactive heatmaps, we'd want tooltips for the measured values as we've done on these heatmaps in the past, and the n_bc indicators are as before. One other one we'd want to add unique to this dataset is single_nt (TRUE/FALSE), which indicates whether an amino acid is accessible via single nt mutations in the naive B cell receptor.
Adds the CDR/FWR annotations to data summary file.
@WillHannon-MCB , this should have the additional annotations then for representation in interactive plots. I think the viz I imagine would be to be able to have four sets of selectors, as toggle-switches where ideally you'd be able to toggle on or off multiple values in each of the sets of selections -- one for selecting mutations based on the wt amino acid (column
wildtype), one for selecting mutations based on th emutated amino acid (columnmutant), one for selecting sites based on their heavy versus light chain (columnchain), one for selecting sites based on their CDR/FWR annotation (columnannotation). Tooltip on points would give the mutation string as represented in the columnmutation, which gives the sites indexed in the desired "IMGT" nomenclature as well as an indicator for heavy/light chain.While I'm listing these things just so it's here in one place, similarly on interactive heatmaps, we'd want tooltips for the measured values as we've done on these heatmaps in the past, and the
n_bcindicators are as before. One other one we'd want to add unique to this dataset issingle_nt(TRUE/FALSE), which indicates whether an amino acid is accessible via single nt mutations in the naive B cell receptor.