jbloomlab / dms_variants

Analyze deep mutational scanning of barcoded variants.
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implement Cauchy likelihood, more robust to noise #22

Closed jbloom closed 4 years ago

jbloom commented 4 years ago

Implement a Cauchy distribution likelihood as an alternative to the Gaussian likelihoods used by Otwinosk et al (2018).

The Cauchy distribution has fatter tails and so should be less susceptible to outliers, which is confirmed in simulations.