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jhkorhonen / MOODS

MOODS: Motif Occurrence Detection Suite
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Does MOODS take into account multiple testing correction? #22

Open doczmp opened 5 years ago

doczmp commented 5 years ago

Hello,

I was just wondering if MOODS uses some kind of multiple testing correction with regards to its p-values like FIMO? I could not find anything in the MOODS paper referring to it.

Thanks

jhkorhonen commented 5 years ago

I guess you mean computing q-values basically? The answer is no; p-value thresholds are simply computed from a background model without further statistical testing.

(Overall, MOODS has been mostly focused on making the scanning part as fast as possible, and mostly assumes that the outputs are then post-processed according to the particular needs of the application at hand.)

doczmp commented 5 years ago

Yep, I was referring to q-values. Thanks a lot for the response.