Removes ISG15 from host proteins

[genegodbold]

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Preferred term label

Removes ISG15 from host proteins

Synonyms

None

Textual definition

Interferon-stimulated gene 15 (ISG15; it has a molecular mass of ~15 kDa) is a small, ubiquitin-like protein that can be added to host proteins (ISGylation) upon infection by an intracellular parasite (https://en.wikipedia.org/wiki/ISG15). It serves as a signal of viral presence. Removal of these dampens inflammation and antiviral signaling. SARS-CoV2 and Crimean Congo Hemorrhagic fever both have proteases that act as deubiquitinases but also serve to remove ISG15 units from host proteins. But most deubiquitinases do not also act as de-ISG15ases (I just made up the latter term.)

Suggested parent term

I am tempted to suggest putting this under "modulates ubiquitin dynamics", but this isn't really ubiquitin so that doesn't make sense. I do not foresee that a parasite protein will be discovered that actually adds ISG15 to host proteins, so I don't think a "modulates ISG15 dynamics" term is needed. Perhaps it would be best to use the parent term for "modulates ubiquitin dynamics"?

Attribution

https://orcid.org/0000-0002-5702-4690

[jproesch]

@genegodbold I'm thinking immune evasion and subversioon...

[genegodbold]

@jproesch Yes, it will certainly be doing that--so as a parent term, then?

[jacakrj1]

Added in terms related to ISGylation under 'mediates immune evasion and subversion'.