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jrs95 / hyprcoloc

Hypothesis Prioritisation in multi-trait Colocalization
https://jrs95.github.io/hyprcoloc/
GNU General Public License v3.0
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Enable to use in Asian populations? #23

Closed 7JVST closed 1 year ago

7JVST commented 2 years ago

Hi there,

I am planning to add colocalization method as a post-GWAS analysis in my study which is solely based on east Asian populations. I have noticed that “coloc”, “enloc” and “eCaviar” are being commonly used for colocalization analysis but all of which are being conducted in European GWAS or European dominant meta-analyses. Some stated that GTEx eQTL data, which might be a part of processing in these tools, was mainly generated from European populations, and thus, it would be difficult to get the accurate results in Asian populations because of LD differences. May I know can I use HyprColoc for colocalization in Asian populations, otherwise, do you have any other recommendations for this issue?

jrs95 commented 1 year ago

Hi,

All colocalization methodology is invariant to the ancestry of the population, so can be used for East Asian samples in the same way as it is used for European samples.

Best wishes,

James