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jrs95 / hyprcoloc

Hypothesis Prioritisation in multi-trait Colocalization
https://jrs95.github.io/hyprcoloc/
GNU General Public License v3.0
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Different trait colocalizations if you increase the number of analyzed traits #29

Open nickhir opened 8 months ago

nickhir commented 8 months ago

Hello, I am currently using hyprcoloc to identify colocalization of ~15 different traits. Some of these traits are pQTLs, others are eQTLs. I noticed, that I get different results depending on the number of traits for which I run the colocalization. For example, if I test for colocalization between traits A, B, C, D, E, hyprcoloc tells me that there is colocalization between traits A, C and D. However, if I include traits F, G, H in the hyprcoloc run, the previously identified colocalization between A, C and D disappears. I do not understand why this would happen...

Furthermore, for some loci I observed colocalization events between traits A, C, D and colocalization between traits A, C, E. Consequently I would expect that there is also colocalization between traits D and E, however, this is not reported.

I would very much appreciate any insights or pointers that would explain my observations.

Cheers!

zhishanchen commented 7 months ago

I have the same observation. Have you figured this out? Thanks.

nickhir commented 7 months ago

No, I still do not fully understand why this is happening :/