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jsh58 / Genrich

Detecting sites of genomic enrichment
MIT License
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Have you considered poisson distribution for q-value calculation? #34

Closed NyxSLY closed 4 years ago

NyxSLY commented 4 years ago

Have you considered poisson distribution for q-value calculation? Is your current method better?

jsh58 commented 4 years ago

I don't understand the question. Please clarify.

NyxSLY commented 4 years ago

Sorry, I didn't read the p-value calculation part in detail. You mentioned that it was better than Poisson distribution.

"Earlier versions of Genrich (prior to v0.5) used the exponential distribution for the null model. Although this distribution has some convenient properties (continuous, one-parameter, -log10(p) ∝ x / β), the study described above showed that the exponential distribution was a good fit to the control pileup distribution only occasionally. However, this was still better than the Poisson distribution, which is frequently used as a null model in genomics software but was a good fit to the control pileup distribution never."