Quickly turning an R4k Indigo (R3k untested) on and off results in the mouse's inputs no longer being recognized when the system comes back up. The keyboard will continue to work, and the issue can be fixed temporarily by unplugging and plugging the adapter back in after the system is powered down. Longer power cycles (e.g. overnight) seem to not have this issue.
Quickly turning an R4k Indigo (R3k untested) on and off results in the mouse's inputs no longer being recognized when the system comes back up. The keyboard will continue to work, and the issue can be fixed temporarily by unplugging and plugging the adapter back in after the system is powered down. Longer power cycles (e.g. overnight) seem to not have this issue.