junseonghwan / PhylEx

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Implement new mixture for single cell likelihood #10

Closed junseonghwan closed 4 years ago

junseonghwan commented 4 years ago

The independence assumption across sites cannot capture branching vs linear structure.

When assigning cell to node v,

junseonghwan commented 4 years ago

Simpler approach is to construct the likelihood as mixture of 3 distributions one for dropout, burst for variant allele, and bi-allelic expression.