jvivian / gene-outlier-detection

A Bayesian model for identifying gene expression outliers for individual single samples (N-of-1) when compared to a cohort of background datasets.
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Normalize epsilon by standard deviation #51

Closed jvivian closed 5 years ago

jvivian commented 5 years ago

Giving every gene the same epsilon causes inappropriate modeling of the x distribution, but integrating the variance into the model error results in large variances in the posterior. Normalizing the standard error as shown below alleviates these issues to some degree. image