Allopurinol and Liver Concerns

[kct2020]

Allopurinol and Liver Concerns Summary

• Page Affected by this Issue: Allopurinol Side Effects & Liver
• Purpose of Issue: To improve information about allopurinol side effects & liver.
• Progress Notes [ explanation ] : Progress Notes for allopurinol and liver concerns.
• Related Pages/Issues: None.
• Status: Waiting for comments from people who are concerned about the effects of allopurinol on the liver.

If you have any contributions to make to improving allopurinol side effects & liver information, add your comments here. Comments here should address specific points covered by, or missing from, Allopurinol Side Effects & Liver. Otherwise, use GoutPal Discussions for chats with fellow gout sufferers.

[kct2020]

During the creation of this page, I discovered related research that I haven't yet included in the published article. Mainly because it is too specialized (e.g. topiroxostat). Zhang, Siliang, Qiming Xie, Shuqing Xie, Jianwei Chen, Qingyue Deng, Ling Zhong, Jing Guo, and Yuan Yu. "The association between urate‐lowering therapies and treatment‐related adverse events, liver damage, and major adverse cardiovascular events (MACE): A network meta‐analysis of randomized trials." Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 41, no. 9 (2021): 781-791. However, I've retained source material in the Progress Notes as it might be useful for future reviews.

At this stage, I regard the page as having sufficient information to allow gout patients to discuss any allopurinol and liver concerns that they may have. So I invite readers to add feedback here if they require clarification or additional information.

If you have any contributions to make to improving allopurinol side effects & liver information, add your comments here. Comments here should address specific points covered by, or missing from, Allopurinol Side Effects & Liver. Otherwise, use GoutPal Discussions for chats with fellow gout sufferers.

[kct2020]

Subsequently, I've added other potentially useful sources to Progress Notes, which I list here. So they're readily available for any new concerns from readers:

• Doghramji, Paul P., Steve Fermer, Robert Wood, Robert Morlock, and Scott Baumgartner. "Management of gout in the real world: current practice versus guideline recommendations." Postgraduate medicine 128, no. 1 (2016): 106-114. Especially, regarding LFTs & KFTs.
• Aldaba-Muruato LR, Moreno MG, Shibayama M, Tsutsumi V, Muriel P. Allopurinol reverses liver damage induced by chronic carbon tetrachloride treatment by decreasing oxidative stress, TGF-β production and NF-κB nuclear translocation. Pharmacology. 2013;92(3–4):138-149.
• Kataoka H, Yang K, Rock KL. The xanthine oxidase inhibitor Febuxostat reduces tissue uric acid content and inhibits injury-induced inflammation in the liver and lung. Eur J Pharmacol. 2015;746:174-179.

If you have any contributions to make to improving allopurinol side effects & liver information, add your comments here. Comments here should address specific points covered by, or missing from, Allopurinol Side Effects & Liver. Otherwise, use GoutPal Discussions for chats with fellow gout sufferers.