keaven / gsDesign

Group sequential design for clinical trials
https://keaven.github.io/gsDesign/
GNU General Public License v3.0
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Update `toBinomialExact()` #167

Open keaven opened 2 months ago

keaven commented 2 months ago

Add capability to produce updated bounds at interim analysis. This requires addition of the following optional arguments with NULL default values: 1) events - a vector with the number of observed events at each analysis 2) alpha - alpha level that may differ from input design; useful for graphical methods or for repeated/sequential p-value and confidence intervals 3) usTime - optional vector to define spending time at each analysis for upper bound 4) lsTime - optional vector to define spending time at each analysis for lower bound

Help file and vignette will need updating. Also writing a section for technical manual.