Currently, all variant predictions with a likelihood score < 0 are, according to our likelihood model, more likely to be inherited or false variants than true de novo variants. However, in practical terms, the cutoff between real and false variants can be substantially higher, possibly depending on other parameters such as k-size. We should consider providing an option to adjust the exact cutoff.
Currently, all variant predictions with a likelihood score < 0 are, according to our likelihood model, more likely to be inherited or false variants than true de novo variants. However, in practical terms, the cutoff between real and false variants can be substantially higher, possibly depending on other parameters such as k-size. We should consider providing an option to adjust the exact cutoff.