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kishwarshafin / pepper

PEPPER-Margin-DeepVariant
MIT License
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Quick question about Deep Learning and Varian Calling #146

Closed ghost closed 2 years ago

ghost commented 2 years ago

Hi, I love the method! But after using it for several weeks I have a doubt... what is the purpose or reason of using Deep Learning for Variant Calling? What do neural networks contribute to this task? Where can I get information about the reason of using Deep Learning in comparison with the classical perspective?

Best regards and thank you very much,

Daniel

kishwarshafin commented 2 years ago

Hello @daniusparres ,

There are several papers that you can read, DeepVariant is the "known" first successful attempt of using DNNs for variant calling, you can read the paper from here: https://www.nature.com/articles/nbt.4235.