When you have that enabled the game is focused after every click, making it hard to use sliders, buttons, etc. Suggestion: disable that feature when settings is open.
I just checked the code, since the option should not apply when in the settings menu as you suggested and found a bug that caused this behaviour. Will be fixed very soon, thanks for the bug report!
When you have that enabled the game is focused after every click, making it hard to use sliders, buttons, etc. Suggestion: disable that feature when settings is open.