Open andreas-wilm opened 3 months ago
Tcrdist by default trims first 3 amino acid and last 2 amino acids so those do not incur a penalty. Trim settings can be modified.
kargs_b= {
'cdr3_b_aa' :
{'use_numba': True,
'distance_matrix': pw.matrices.tcr_nb_distance_matrix,
'dist_weight': 1,
'gap_penalty':4,
'ntrim':3,
'ctrim':2,
'fixed_gappos': False},
Hi @kmayerb,
I came across a case, where two TCRs differ by an A to P change in their CDR3, but their distance is 0. How come?
Many thanks, Andreas
PS: Tested with version 0.2.2