I have TCR data from 5 different conditions and want to use TCRdist3 to show, for example, that clones in group 1 are more similar to those in groups 2 and 3, while clones in group 4 are more similar to group 5. I have run the metaclonotype pipeline but unsure how to utilize the results.
Compute the pairwise distances between all clones. Then compute average distance within and between groups. If you attempt and share some code I might be able to provide additional insight.
Hi,
I have TCR data from 5 different conditions and want to use TCRdist3 to show, for example, that clones in group 1 are more similar to those in groups 2 and 3, while clones in group 4 are more similar to group 5. I have run the metaclonotype pipeline but unsure how to utilize the results.