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kmayerb / tcrdist3

flexible CDR based distance metrics
MIT License
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How to compare clonal similarity between different groups? #84

Closed sc30301 closed 1 year ago

sc30301 commented 1 year ago

Hi,

I have TCR data from 5 different conditions and want to use TCRdist3 to show, for example, that clones in group 1 are more similar to those in groups 2 and 3, while clones in group 4 are more similar to group 5. I have run the metaclonotype pipeline but unsure how to utilize the results.

kmayerb commented 1 year ago

Compute the pairwise distances between all clones. Then compute average distance within and between groups. If you attempt and share some code I might be able to provide additional insight.