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konradjk / loftee

MIT License
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Suggested GERP bigwig download path is very slow and possibly out-of-date #96

Open dvg-p4 opened 1 year ago

dvg-p4 commented 1 year ago

The suggested path to find the GERP file is:

https://personal.broadinstitute.org/konradk/loftee_data/GRCh38/gerp_conservation_scores.homo_sapiens.GRCh38.bw

This is taking multiple hours for me to download, at a speed of about 1000k-2500k. The (as far as I can tell) original source of the file at

~ftp://ftp.ensembl.org/pub/current_compara/conservation_scores/88_mammals.gerp_conservation_score/gerp_conservation_scores.homo_sapiens.GRCh38.bw~

[edit 2024-06-27:]

https://ftp.ensembl.org/pub/current_compara/conservation_scores/91_mammals.gerp_conservation_score/gerp_conservation_scores.homo_sapiens.GRCh38.bw

is downloading much faster (~9000k). Also it's a slightly different size, making me think that the one at your personal download site may be out-of-date.

dvg-p4 commented 1 week ago

Looks like they've updated the conservation scores since I originally posted this ticket