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kstreet13 / slingshot

Functions for identifying and characterizing continuous developmental trajectories in single-cell data.
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steps you have to take after slingshot #197

Closed FADHLyemen closed 1 year ago

FADHLyemen commented 1 year ago

sorry, this is not an issue, it is only a question. I used slingshot to estimate pesudotime. The density plot of pesudotime showed early disease came easily in the trajectory and late disease came later. if I want to identify which genes are responsible for disease progression, which steps I should take? Thank you

kstreet13 commented 1 year ago

Hi @FADHLyemen ,

I would definitely recommend checking out the tradeSeq package. Specifically, the associationTest is designed to find genes that play an important role in a particular lineage.

Best, Kelly