XBG | BA.2.76/BA.5.2

[ktmeaton]

• pango-designation issue: # 896
• covSPECTRUM query:

Parents

Clade: BA.2.76,BA.5.2 Lineage: BA.2.75*,BA.5.2* Lineage Confidence: 0.775,0.977

Immunity

RBD Level: 4 RBD Substitutions: S:R346T,S:L452R,S:F486V,S:R493Q Immune Escape: 0.601 ACE2 Binding: 0.670

Immune Escape Ranking

Higher values indicate an increased capacity to evade antibodies.

TBD

ACE2 Binding Ranking

Higher values indicate an increased capacity for viral entry into the host cell.

TBD

Alleles

XBG is successfully detected with the sc2rf mode for VOC:

python3 sc2rf/sc2rf.py results/XBG/nextclade/alignment.fasta --max-name-length 50 --clades BA.2.10 BA.2.3.17 BA.2.3.20 BA.2.75 BA.2.76 BA.4.6 BA.5.2 BA.5.3 XBB --ansi --parents 2-4 --breakpoints 1-5 --unique 1 --max-ambiguous 20 --max-intermission-length 2 --max-intermission-count 3 --ignore-shared --mutation-threshold 0.25 --csvfile results/XBG/sc2rf/stats.voc.csv

Breakpoints

Breakpoint 1: 22600:22916

Tasks

• [x] resources/breakpoints.tsv Updated