XBP | BA.2.75/BQ.1

[ktmeaton]

• pango-designation issue: #1393
• covSPECTRUM query: TBD

Parents

Clade: Omicron/BA.2.75/22D,Omicron/BA.5/22B Lineage: BA.2.75*,BQ.1.1* Lineage Confidence: 0.993,0.408

Immunity

RBD Level: 5 RBD Substitutions: S:K444T,S:L452R,S:N460K,S:F486V,S:R493Q Immune Escape: 0.631 ACE2 Binding: 0.664

Immune Escape Ranking

Higher values indicate an increased capacity to evade antibodies.

TBD

ACE2 Binding Ranking

Higher values indicate an increased capacity for viral entry into the host cell.

TBD

Alleles

proposed1393 is successfully detected with the sc2rf mode for XBB:

python3 sc2rf/sc2rf.py results/proposed1393/nextclade/alignment.fasta --max-name-length 50 --clades BA.2.10 BA.2.75 BA.4 BA.5 --ansi --parents 2 --breakpoints 1-3 --unique 1 --max-ambiguous 20 --max-intermission-length 2 --max-intermission-count 3 --ignore-shared --mutation-threshold 0.25 --csvfile results/proposed1393/sc2rf/stats.XBB.csv

Breakpoints

Breakpoint 1: 22191:22330

Tasks

• [x] resources/breakpoints.tsv Updated

[ktmeaton]

Update, this is now XBP.