proposed1425 | BA.2.75/BQ.1

[ktmeaton]

• pango-designation issue: #1425
• covSPECTRUM query: TBD

Parents

Clade: Omicron/CJ.1,Omicron/BA.5.3,Omicron/CJ.1 Lineage: BA.2.75*,BQ.1.1*,BA.2.75* Lineage Confidence: 1.0,0.398,0.748

Immunity

RBD Level: 6 RBD Substitutions: S:R346T,S:K444T,S:L452R,S:N460K,S:F486V,S:R493Q Immune Escape: 0.839 ACE2 Binding: 0.748

Immune Escape Ranking

Higher values indicate an increased capacity to evade antibodies.

TBD

ACE2 Binding Ranking

Higher values indicate an increased capacity for viral entry into the host cell.

TBD

Alleles

proposed1425 is successfully detected with the sc2rf mode for VOC:

python3 sc2rf/sc2rf.py results/proposed1425/nextclade/alignment.fasta --max-name-length 50 --clades BA.2.10 BA.2.3.17 BA.2.3.20 BA.2.75 BA.2.76 BA.4.6 BA.5.2 BA.5.3 XBB CJ.1 --ansi --parents 2-4 --breakpoints 1-5 --unique 1 --max-ambiguous 20 --max-intermission-length 2 --max-intermission-count 3 --ignore-shared --mutation-threshold 0.25 --csvfile results/proposed1425/sc2rf/stats.voc.csv

Breakpoints

Breakpoint 1: 22578:22892 Breakpoint 2: 25417:26274

Tasks

• [x] resources/breakpoints.tsv Updated