Literature and background

[sigmafelix]

• Questions
  • What is the recent status of knowledge in the relationship between genotypes, environmental exposures, and depression?
    • What genotypes have been discovered to explain depression?
      • Biomarker reference: Baumeister et al. 2014
      • Brain inflammation,
    • What kind of mediators or confounders are often considered in the literature?
    • When is the crucial period of environmental mixtures on the onset, duration, and/or prognosis of depression?
  • Which neighborhood definition would be associated with the significant effect of environmental exposures on depression after controlling other factors?
• Tentative goals
  • With PEGS, this study aims to examine effects of the mixture of environmental exposures encompassing climate, air pollution, and green/bluespace on depression
  • Bayesian Kernel Machine Regression is leveraged to estimate the dose-response surfaces of mixtures
• Quick TODO:
  • Literature review
    • [x] Previous studies using PEGS data
    • [ ] Brain inflammation, genotypes, and depression
    • [ ] List of environmental exposures and covariates used in the literature
    • [ ] Understanding BKMR and recent advancements inspired by BKMR
  • Defining a pathway (deliverable): cf. DAG in Fig. 2 from Lowe et al. 2022