Need to set damage to daughter cells

[drbergman]

Many of my sims have grey cells showing up amongst all the maroon ones. How do they have no damage? They're probably just recently born from a damaged parent cell.

After running once with 0 proliferation, this did not occur. This further validates that these gray cells in the maroon ones are new daughter cells.

Should damage be inherited? Should damage be split between them? The drug should definitely be split between them, yeah?

[laurenpmarazzi]

This is a great question.

My initial thought is that if a cell has damage but then repairs and goes on to proliferate, that the cell would no longer be damaged, essentially reverting back to normal tumor cell.

However, the cell could have repaired enough damage to pass M phase checkpoints, but could still have damage, leading to genomic instability and a more malicious tumor cell (acquiring resistance).

I think the simpliest thing at the moment would be that if a cell can proliferate, then all damage has been repaired, and it is a normal tumor cell. The amount of drug should be set back to 0 for the daughter cells of repaired cells, with the idea that they would be killed by a new round of treatment.

[drbergman]

As per our conversation, let's set a threshold on damage above which the cell no longer proliferates.

Stretch goal: Damage > prolif_threshold ==> no prolif mutation_threshold_damage < Damage < prolif_threshold ==> can proliferate and if it does, could acquire mutation/resistance Damage < mutation_threshold_damage ==> can proliferate without chance of mutation/resistance