Thanks for developing a fantastic tool for the community. I'm running into a liftOver issue within another package, and thought I would raise the issue here.
Namely, when I try to liftover the GRCh37 coordinates to GRCh38 for the SNP rs190850470, I see the following output:
rs190850470 chrX:50858748 -> rs190850470 chr2:33174205, which is at odds with the dbSNP entry.
Is this a bug within the R liftOver implementation, or is this an artifact liftOver algorithm itself? I found the UCSC browser gives the same mapping to chr2. Alternatively, I've found that NCBI remap correctly maps the variant to chrX:51115913. So I'm not sure what the path forward is here.
Any help or insights would be greatly appreciated.
Hi all,
Thanks for developing a fantastic tool for the community. I'm running into a liftOver issue within another package, and thought I would raise the issue here.
Namely, when I try to liftover the GRCh37 coordinates to GRCh38 for the SNP
rs190850470
, I see the following output:rs190850470 chrX:50858748
->rs190850470 chr2:33174205
, which is at odds with the dbSNP entry.Is this a bug within the R liftOver implementation, or is this an artifact liftOver algorithm itself? I found the UCSC browser gives the same mapping to
chr2
. Alternatively, I've found that NCBI remap correctly maps the variant tochrX:51115913
. So I'm not sure what the path forward is here.Any help or insights would be greatly appreciated.