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lehner-lab / DiMSum

An error model and pipeline for analyzing deep mutational scanning (DMS) data and diagnosing common experimental pathologies
MIT License
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Enable --mutagenesisType codon & --maxSubstitutions 1 #14

Open MaximilianStammnitz opened 1 year ago

MaximilianStammnitz commented 1 year ago

@andrefaure would it be possible in future to also enable the following option: --mutagenesisType codon --maxSubstitutions 1

DimSum (v1.2.11) complains about this: "Error: Invalid 'maxSubstitutions' argument. Only integers greater than 1 allowed."

... there's surely some applications in which users only want to look at single aa changes (without also providing the full table of expected/permitted variants). :-)

Originally posted by @MaximilianStammnitz in https://github.com/lehner-lab/DiMSum/issues/13#issuecomment-1609309426

andrefaure commented 1 year ago

Very few applications - this is low priority. I recommend just running with default settings and filter for singles yourself from the output (no need to provide a table of designed variants).