There are some genes where we want to segregate mutations by specific amino acid change when creating plots. Examples: DNMT3A (R882 vs Other muts), FLT3 (ITD vs D835 v other)
There are a couple of options, as I see it:
1) define an "alias" or "mutational group" field that specifies these special cases and handles them as distinct entities
2) add a UI element (pulldown?) that shows all of the mutations for a specific gene and allows you select changes to segregate out. There are additional questions here (Does R882H == R882C?) but would be more general/purpose flexible at the expense of adding some complexity.
It's possible that we implement 1 to start and keep 2 as a future goal
There are some genes where we want to segregate mutations by specific amino acid change when creating plots. Examples: DNMT3A (R882 vs Other muts), FLT3 (ITD vs D835 v other)
There are a couple of options, as I see it: 1) define an "alias" or "mutational group" field that specifies these special cases and handles them as distinct entities
2) add a UI element (pulldown?) that shows all of the mutations for a specific gene and allows you select changes to segregate out. There are additional questions here (Does R882H == R882C?) but would be more general/purpose flexible at the expense of adding some complexity.
It's possible that we implement 1 to start and keep 2 as a future goal