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lh3 / hickit

TAD calling, phase imputation, 3D modeling and more for diploid single-cell Hi-C (Dip-C) and general Hi-C
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Help with bulk Hi-C data #37

Closed jeff-godwin closed 1 year ago

jeff-godwin commented 1 year ago

Dear hickit team,

I am using bulk Hi-C data from yeast for 3D modelling. It has been explicitly mentioned that the modelling functionality does not apply to bulk data. However this publication (https://www.nature.com/articles/s41594-019-0205-2 - Analysis of 3D genome structures under Methods section) has adopted the same with mice data. I'm wondering if I can tweak the pipeline for yeast data as well. It will be very helpful to know your thoughts.

I'm running a couple of iterations with my data. I will let you know if something comes up.

Thanks, Jeffrey

lh3 commented 1 year ago

hickit is not intended for modeling bulk Hi-C.