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lhe17 / nebula

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Does the P value of the control vs. treatment represent the information of the covariates? #10

Open MANZHAOHUI opened 1 year ago

MANZHAOHUI commented 1 year ago

Hi Liang, I am doing DE test upon 'normal' and 'alzheimer' cells with the correction from other covariates such as age, sex, PMI, library size. Nebula generates p values for all the covariates including the nomal vs. disease (cccontrol in your vignettes), which is the one I am interested in. My question is whether the p value of the 'cccontrol' has already been corrected by the information from other predictors/coviates or if there is any way to extract p value of the two groups comparison with the correction from all the predictors/covariates? Thank you. Best. Zhaohui Man

lhe17 commented 1 year ago

Yes, it adjusts for the other covariates in your design matrix.

Best regards, Liang

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MANZHAOHUI commented 1 year ago

Thank you very much for the prompt reply.