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is it possible to put an interaction term in Nebula? #47

Open MANZHAOHUI opened 3 months ago

MANZHAOHUI commented 3 months ago

Hi Dr. He, I am wondering if It is possible to put an interaction term in Nebula. I am looking at some sex specific effects in the single cell data and was wanting to set up a model like

Y ~ age + sex + diagnosis + sex*diagnosis + random(sample) + PMI

Is it feasible to use sex*diagnosis term? Thank you.

lhe17 commented 3 months ago

Hi Zhaohui,

Thank you for your question.

Yes, you can. You just need to add the interaction term when building the design matrix. Please see my reply to the previous question https://github.com/lhe17/nebula/issues/16

Best regards, Liang

On Tue, Mar 26, 2024 at 12:48 PM ZHAOHUI MAN @.***> wrote:

Hi Dr. He, I am wondering if It is possible to put an interaction term in Nebula. I am looking at some sex specific effects in the single cell data and was wanting to set up a model like

Y ~ age + sex + diagnosis + sex*diagnosis + random(sample) + PMI

Is it feasible to use sex*diagnosis term? Thank you.

— Reply to this email directly, view it on GitHub https://github.com/lhe17/nebula/issues/47, or unsubscribe https://github.com/notifications/unsubscribe-auth/AGDISUWS5EGKHUS2H5JSCP3Y2GRFDAVCNFSM6AAAAABFJJ3CACVHI2DSMVQWIX3LMV43ASLTON2WKOZSGIYDQNZYGA3TGNY . You are receiving this because you are subscribed to this thread.Message ID: @.***>

MANZHAOHUI commented 3 months ago

Thank you. It is very helpful.