I cannot install LMDE (v3, v4) or Debian (v10.3) from an ISO file stored on a NTFS volume - the installer fails before it reaches the live desktop with the error message "Unable to find a medium containing a live file system". Installation works fine when the ISO file is stored on a FAT32 volume. I believe that the problem is caused by the inability of the initial ramdisk image used by LMDE and Debian to understand NTFS volumes.
For many people NTFS is the de facto file system for data volumes because it is well supported by both Linux and Windows; Windows support for ext volumes is very poor. NTFS is also more space-efficient, robust and secure than FAT32.
This problem does not affect any edition of Linux Mint which I have tested (v18.0 to 19.3 inclusive, Cinnamon desktop).
I cannot install LMDE (v3, v4) or Debian (v10.3) from an ISO file stored on a NTFS volume - the installer fails before it reaches the live desktop with the error message "Unable to find a medium containing a live file system". Installation works fine when the ISO file is stored on a FAT32 volume. I believe that the problem is caused by the inability of the initial ramdisk image used by LMDE and Debian to understand NTFS volumes. For many people NTFS is the de facto file system for data volumes because it is well supported by both Linux and Windows; Windows support for ext volumes is very poor. NTFS is also more space-efficient, robust and secure than FAT32. This problem does not affect any edition of Linux Mint which I have tested (v18.0 to 19.3 inclusive, Cinnamon desktop).