Closed sterrettJD closed 8 months ago
Seems like KEGG moved RN
from DBLINKS
to its own field named REACTION
! KEGG_Parser needs to be updated to address this.
Used to look like:
ENTRY K00006 KO
SYMBOL GPD1
NAME glycerol-3-phosphate dehydrogenase (NAD+) [EC:1.1.1.8]
PATHWAY map00564 Glycerophospholipid metabolism
map01110 Biosynthesis of secondary metabolites
map04011 MAPK signaling pathway - yeast
DISEASE H00728 Brugada syndrome
BRITE KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
09103 Lipid metabolism
00564 Glycerophospholipid metabolism
K00006 GPD1; glycerol-3-phosphate dehydrogenase (NAD+)
09130 Environmental Information Processing
09132 Signal transduction
04011 MAPK signaling pathway - yeast
K00006 GPD1; glycerol-3-phosphate dehydrogenase (NAD+)
Enzymes [BR:ko01000]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.8 glycerol-3-phosphate dehydrogenase (NAD+)
K00006 GPD1; glycerol-3-phosphate dehydrogenase (NAD+)
DBLINKS COG: COG0240
GO: 0004367
RN: R00842
Now this is the format:
ENTRY K00006 KO
SYMBOL GPD1
NAME glycerol-3-phosphate dehydrogenase (NAD+) [EC:1.1.1.8]
PATHWAY map00564 Glycerophospholipid metabolism
map01110 Biosynthesis of secondary metabolites
map04011 MAPK signaling pathway - yeast
REACTION R00842 sn-glycerol-3-phosphate:NAD+ 2-oxidoreductase
DISEASE H00728 Brugada syndrome
BRITE KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
09103 Lipid metabolism
00564 Glycerophospholipid metabolism
K00006 GPD1; glycerol-3-phosphate dehydrogenase (NAD+)
09130 Environmental Information Processing
09132 Signal transduction
04011 MAPK signaling pathway - yeast
K00006 GPD1; glycerol-3-phosphate dehydrogenase (NAD+)
Enzymes [BR:ko01000]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.8 glycerol-3-phosphate dehydrogenase (NAD+)
K00006 GPD1; glycerol-3-phosphate dehydrogenase (NAD+)
DBLINKS COG: COG0240
GO: 0004367
Addressed in https://github.com/lozuponelab/AMON/pull/20
This is a new issue...
With polyomic dataset
Previously was:
REACTION was added 2 weeks ago the to KEGG_Parser KO not captured fields - I wonder if something is going on there. If it isn't there, the parser errors with "What is REACTION in?"