Develop the example of the olfactory system for the counting of cell types

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Arguments for hundreds of types is present across the literature:

"Of the estimated several million neurons lining the olfactory cleft, there exist approximately 350 functionally distinct “types” of OSNs in humans, scattered in broad zones, with each “type” of neuron defined by its expression of one specific OR gene from a repertoire of 350 possible genes"

https://doi.org/10.1002/LIO2.135

Also present in "Cem Bilhoes de Neuronios?"

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OSNs expressing the same Olfr share similar odorant response profiles (Malnic et al., 1999; Nara et al., 2011) and drive their axons to the same glomeruli in the olfactory bulb (Mombaerts et al., 1996; Ressler et al., 1994; Vassar et al., 1994). Thus, Olfrs define functional units in the olfactory system and function as genetic markers to discriminate between different mature OSN subtypes (Ibarra-Soria et al., 2017; Saraiva et al., 2015b).

https://doi.org/10.1016/J.CELREP.2022.110547

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The mouse olfactory sensory neuron (OSN) repertoire is composed of 10 million cells and each expresses one olfactory receptor (OR) gene from a pool of over 1000. Thus, the nose is sub-stratified into more than a thousand OSN subtypes.

https://elifesciences.org/articles/21476

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VERY GOOD REFERENCE A transcriptional rheostat couples past activity to future sensory responses

https://www.sciencedirect.com/science/article/pii/S0092867421013374?via%3Dihub

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Good reference for humans https://www.nature.com/articles/s41593-020-0587-9

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"Minting identifiers for more than 1000 types of olfactory sensory neurons"

Query for mouse OR genes: https://w.wiki/5Pzt Reference: Q112689286 Stated as: "There are ∼1,000 different olfactory sensory neuron (OSN) subtypes in the mouse, each of which can be identified across individuals based upon its expression of a single odorant receptor (OR)"

Query for human OR genes: https://w.wiki/5P$H Reference: Q98844101 Stated as: "Cada célula do epitélio olfatório expressa um dos genes funcionais , que produz uma proteína receptora (...) Portanto, temos em nossa mucosa nasal pelo menos 400 tipos diferentes de neurônios receptors olfatórios, cada um especialista em detectar um determinado odorante"

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Olfactory receptors that are markers of non-olfactory receptor cells: https://w.wiki/5Pzy