Q: Tumor only variant calling

luntergroup / octopus

Bayesian haplotype-based mutation calling

MIT License

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Closed kokyriakidis closed 2 years ago

kokyriakidis commented 3 years ago

Hi!

Do you have any recent benchmarks regarding Tumor only variant calling (vs Mutect)?

Thanks, Konstantinos

dancooke commented 3 years ago

Hi, we presented some tumour-only benchmarks in the Nature Biotechnology paper. We don't compare to Mutect2 as this tool doesn't officially support tumour-only calling - it doesn't try to classify germline and somatic variants.