I 'm confused about the difference between two data files.

luoyunan / DTINet

A Network Integration Approach for Drug-Target Interaction Prediction

GNU General Public License v3.0

172 stars 60 forks source link

I 'm confused about the difference between two data files. #6

Closed yangxinhaosmu closed 5 years ago

yangxinhaosmu commented 5 years ago

My question may be a little stupid..... What's the difference between Similarity_Matrix_Drugs.txt and Sim_mat_drug_drug.txt which is generated by compute_similarity.m in matlab? Can Sim_mat_drug_drug.txt presents the structural similarities of drugs based on drug compounds’ chemical structures? What does the Drug similarity scores mean? If the information is confidential，please forgive my rudeness. Thanks a lot!

luoyunan commented 5 years ago

Hi @yangxinhaosmu Similarity_Matrix_Drugs.txt is the structure similarity (Tonimoto scores of chemical structures). Sim_mat_drug_drug.txt is the pairwise similarity (Jaccard similarity) based on drug-drug interaction profile.

yangxinhaosmu commented 5 years ago

Thank you so much!